Human Cytomegalovirus Antigen Presentation by HLA-DR+ NKG2C+ Adaptive NK Cells Specifically Activates Polyfunctional Effector Memory CD4+ T Lymphocytes
Identifieur interne : 000773 ( Main/Exploration ); précédent : 000772; suivant : 000774Human Cytomegalovirus Antigen Presentation by HLA-DR+ NKG2C+ Adaptive NK Cells Specifically Activates Polyfunctional Effector Memory CD4+ T Lymphocytes
Auteurs : Marcel Costa-García [Espagne] ; Michelle Ataya [Espagne] ; Manuela Moraru [Espagne] ; Carlos Vilches [Espagne] ; Miguel L Pez-Botet [Espagne] ; Aura Muntasell [Espagne]Source :
- Frontiers in Immunology [ 1664-3224 ] ; 2019.
Abstract
Natural killer (NK) cells play a dual role in the defense against viral pathogens by directly lysing infected cells as well as by regulating anti-viral T cell immunity. Infection by human cytomegalovirus (HCMV) promotes a persistent expansion of NKG2C+ adaptive NK cells which have been shown to display enhanced antibody-dependent responses against infected targets and associated to viral control in transplanted patients. Based on gene expression data showing increased transcription of CIITA and several genes related to the MHC class II pathway in adaptive NK cells, we explored their putative capacity for antigen presentation to CD4+ T cells. Phenotypic analysis confirmed a preferential steady-state expression of HLA-DR by circulating NKG2C+ adaptive NK cells in healthy individuals. Expression of HLA-DR in NKG2C+ adaptive NK cells was variable and unrelated to the expression of activation (i.e., CD69 and CD25) or differentiation (i.e., FcRγ chain, CD57) markers, remaining stable over time at the individual level. Incubation of purified NK cells with HCMV complexed with serum specific antibodies induced an up-regulation of surface HLA-DR concomitant to CD16 loss whereas no changes in CD80/CD86 co-stimulatory ligands were detected. In addition, surface CX3CR1 decreased upon antigen-loading while HLA-DR+ NK cells maintained a CCR7-, CXCR3low homing profile. Remarkably, HCMV-loaded purified NK cells activated autologous CD4+ T cells in an HLA-DR dependent manner. The fraction of T lymphocytes activated by antigen-loaded NK cells was smaller than that stimulated by monocyte-derived dendritic cells, corresponding to CD28-negative effector-memory CD4+ T cells with cytotoxic potential. Antigen presentation by NK cells activated a polyfunctional CD4+ T cell response characterized by degranulation (CD107a) and the secretion of Th1 cytokines (IFNγ and TNFα). Overall, our data discloses the capacity of NKG2C+ adaptive NK cells to process and present HCMV antigens to memory CD4+ cytotoxic T cells, directly regulating their response to the viral infection.
Url:
DOI: 10.3389/fimmu.2019.00687
PubMed: 31001281
PubMed Central: 6456717
Affiliations:
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strict</wicri:regionArea></affiliation></author><author><name sortKey="Muntasell, Aura" sort="Muntasell, Aura" uniqKey="Muntasell A" first="Aura" last="Muntasell">Aura Muntasell</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Hospital del Mar Medical Research Institute (IMIM)</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31001281</idno><idno type="pmc">6456717</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456717</idno><idno type="RBID">PMC:6456717</idno><idno type="doi">10.3389/fimmu.2019.00687</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000535</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000535</idno><idno 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wicri:level="1"><nlm:aff id="aff1"><institution>Department of Experimental and Health Sciences, University Pompeu Fabra</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ataya, Michelle" sort="Ataya, Michelle" uniqKey="Ataya M" first="Michelle" last="Ataya">Michelle Ataya</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Hospital del Mar Medical Research Institute (IMIM)</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Moraru, Manuela" sort="Moraru, Manuela" uniqKey="Moraru M" first="Manuela" last="Moraru">Manuela Moraru</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Immunogenetics and HLA Laboratory, Instituto Hospital Universitario Puerta de Hierro</institution>,<addr-line>Majadahonda</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vilches, Carlos" sort="Vilches, Carlos" uniqKey="Vilches C" first="Carlos" last="Vilches">Carlos Vilches</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Immunogenetics and HLA Laboratory, Instituto Hospital Universitario Puerta de Hierro</institution>,<addr-line>Majadahonda</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="L Pez Botet, Miguel" sort="L Pez Botet, Miguel" uniqKey="L Pez Botet M" first="Miguel" last="L Pez-Botet">Miguel L Pez-Botet</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Experimental and Health Sciences, University Pompeu Fabra</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Hospital del Mar Medical Research Institute (IMIM)</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Muntasell, Aura" sort="Muntasell, Aura" uniqKey="Muntasell A" first="Aura" last="Muntasell">Aura Muntasell</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Hospital del Mar Medical Research Institute (IMIM)</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Immunology</title><idno type="eISSN">1664-3224</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Natural killer (NK) cells play a dual role in the defense against viral pathogens by directly lysing infected cells as well as by regulating anti-viral T cell immunity. Infection by human cytomegalovirus (HCMV) promotes a persistent expansion of NKG2C+ adaptive NK cells which have been shown to display enhanced antibody-dependent responses against infected targets and associated to viral control in transplanted patients. Based on gene expression data showing increased transcription of CIITA and several genes related to the MHC class II pathway in adaptive NK cells, we explored their putative capacity for antigen presentation to CD4+ T cells. Phenotypic analysis confirmed a preferential steady-state expression of HLA-DR by circulating NKG2C+ adaptive NK cells in healthy individuals. Expression of HLA-DR in NKG2C+ adaptive NK cells was variable and unrelated to the expression of activation (i.e., CD69 and CD25) or differentiation (i.e., FcRγ chain, CD57) markers, remaining stable over time at the individual level. Incubation of purified NK cells with HCMV complexed with serum specific antibodies induced an up-regulation of surface HLA-DR concomitant to CD16 loss whereas no changes in CD80/CD86 co-stimulatory ligands were detected. In addition, surface CX3CR1 decreased upon antigen-loading while HLA-DR+ NK cells maintained a CCR7-, CXCR3<sup>low</sup> homing profile. Remarkably, HCMV-loaded purified NK cells activated autologous CD4+ T cells in an HLA-DR dependent manner. The fraction of T lymphocytes activated by antigen-loaded NK cells was smaller than that stimulated by monocyte-derived dendritic cells, corresponding to CD28-negative effector-memory CD4+ T cells with cytotoxic potential. Antigen presentation by NK cells activated a polyfunctional CD4+ T cell response characterized by degranulation (CD107a) and the secretion of Th1 cytokines (IFNγ and TNFα). Overall, our data discloses the capacity of NKG2C+ adaptive NK cells to process and present HCMV antigens to memory CD4+ cytotoxic T cells, directly regulating their response to the viral infection.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Crumpacker, C" uniqKey="Crumpacker C">C Crumpacker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boeckh, M" uniqKey="Boeckh M">M Boeckh</name></author><author><name sortKey="Ljungman, P" uniqKey="Ljungman P">P Ljungman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fishman, Ja" uniqKey="Fishman J">JA Fishman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pass, Rf" uniqKey="Pass R">RF Pass</name></author><author><name sortKey="Fowler, Kb" uniqKey="Fowler K">KB Fowler</name></author><author><name sortKey="Boppana, Sb" uniqKey="Boppana S">SB Boppana</name></author><author><name sortKey="Britt, Wj" uniqKey="Britt W">WJ Britt</name></author><author><name sortKey="Stagno, S" uniqKey="Stagno S">S Stagno</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brodin, P" uniqKey="Brodin P">P Brodin</name></author><author><name sortKey="Jojic, V" uniqKey="Jojic V">V Jojic</name></author><author><name sortKey="Gao, T" uniqKey="Gao T">T Gao</name></author><author><name sortKey="Bhattacharya, S" uniqKey="Bhattacharya S">S Bhattacharya</name></author><author><name sortKey="Angel, Cjl" uniqKey="Angel C">CJL Angel</name></author><author><name sortKey="Furman, D" uniqKey="Furman D">D Furman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crough, T" uniqKey="Crough T">T Crough</name></author><author><name sortKey="Khanna, R" uniqKey="Khanna R">R Khanna</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klenerman, P" uniqKey="Klenerman P">P Klenerman</name></author><author><name sortKey="Oxenius, A" uniqKey="Oxenius A">A Oxenius</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sester, M" uniqKey="Sester M">M Sester</name></author><author><name sortKey="Sester, U" uniqKey="Sester U">U Sester</name></author><author><name sortKey="G Rtner, B" uniqKey="G Rtner B">B Gärtner</name></author><author><name sortKey="Kubuschok, B" uniqKey="Kubuschok B">B Kubuschok</name></author><author><name sortKey="Girndt, M" uniqKey="Girndt M">M Girndt</name></author><author><name sortKey="Meyerhans, A" uniqKey="Meyerhans A">A Meyerhans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pourgheysari, B" uniqKey="Pourgheysari B">B Pourgheysari</name></author><author><name sortKey="Khan, N" uniqKey="Khan N">N Khan</name></author><author><name sortKey="Best, D" uniqKey="Best D">D Best</name></author><author><name sortKey="Bruton, R" uniqKey="Bruton R">R Bruton</name></author><author><name sortKey="Nayak, L" uniqKey="Nayak L">L Nayak</name></author><author><name sortKey="Moss, Pah" uniqKey="Moss P">PAH Moss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Leeuwen, Em" uniqKey="Van Leeuwen E">EM van Leeuwen</name></author><author><name sortKey="Remmerswaal, Eb" uniqKey="Remmerswaal E">EB Remmerswaal</name></author><author><name sortKey="Heemskerk, Mh" uniqKey="Heemskerk M">MH Heemskerk</name></author><author><name sortKey="Ten Berge, Ij" uniqKey="Ten Berge I">IJ ten Berge</name></author><author><name sortKey="Van Lier, Ra" uniqKey="Van Lier R">RA van Lier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pachnio, A" uniqKey="Pachnio A">A Pachnio</name></author><author><name sortKey="Ciaurriz, M" uniqKey="Ciaurriz M">M Ciaurriz</name></author><author><name sortKey="Begum, J" uniqKey="Begum J">J Begum</name></author><author><name sortKey="Lal, N" uniqKey="Lal N">N Lal</name></author><author><name sortKey="Zuo, J" uniqKey="Zuo J">J Zuo</name></author><author><name sortKey="Beggs, A" uniqKey="Beggs A">A Beggs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jackson, Se" uniqKey="Jackson S">SE Jackson</name></author><author><name sortKey="Sedikides, Gx" uniqKey="Sedikides G">GX Sedikides</name></author><author><name sortKey="Mason, Gm" uniqKey="Mason G">GM Mason</name></author><author><name sortKey="Okecha, G" uniqKey="Okecha G">G Okecha</name></author><author><name sortKey="Wills, Mr" uniqKey="Wills M">MR Wills</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rentenaar, Rj" uniqKey="Rentenaar R">RJ Rentenaar</name></author><author><name sortKey="Gamadia, Le" uniqKey="Gamadia L">LE Gamadia</name></author><author><name sortKey="Van Derhoek, N" uniqKey="Van Derhoek N">N van DerHoek</name></author><author><name sortKey="Van Diepen, Fn" uniqKey="Van Diepen F">FN van Diepen</name></author><author><name sortKey="Boom, R" uniqKey="Boom R">R Boom</name></author><author><name sortKey="Weel, Jf" uniqKey="Weel J">JF Weel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Leeuwen, Em" uniqKey="Van Leeuwen E">EM van Leeuwen</name></author><author><name sortKey="Remmerswaal, Eb" uniqKey="Remmerswaal E">EB Remmerswaal</name></author><author><name sortKey="Vossen, Mt" uniqKey="Vossen M">MT Vossen</name></author><author><name sortKey="Rowshani, At" uniqKey="Rowshani A">AT Rowshani</name></author><author><name sortKey="Wertheim Van Dillen, Pm" uniqKey="Wertheim Van Dillen P">PM Wertheim-van Dillen</name></author><author><name sortKey="Van Lier, Ra" uniqKey="Van Lier R">RA van Lier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guma, M" uniqKey="Guma M">M Gumá</name></author><author><name sortKey="Angulo, A" uniqKey="Angulo A">A Angulo</name></author><author><name sortKey="Vilches, C" uniqKey="Vilches C">C Vilches</name></author><author><name sortKey="G Mez Lozano, N" uniqKey="G Mez Lozano N">N Gómez-Lozano</name></author><author><name sortKey="Malats, N" uniqKey="Malats N">N Malats</name></author><author><name sortKey="L Pez Botet, M" uniqKey="L Pez Botet M">M López-Botet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="L Pez Botet, M" uniqKey="L Pez Botet M">M López-Botet</name></author><author><name sortKey="Muntasell, A" uniqKey="Muntasell A">A Muntasell</name></author><author><name sortKey="Vilches, C" uniqKey="Vilches C">C Vilches</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beziat, V" uniqKey="Beziat V">V Béziat</name></author><author><name sortKey="Liu, L" uniqKey="Liu L">L Liu</name></author><author><name sortKey="Malmberg, J A" uniqKey="Malmberg J">J-A Malmberg</name></author><author><name sortKey="Ivarsson, Ma" uniqKey="Ivarsson M">MA Ivarsson</name></author><author><name sortKey="Sohlberg, E" uniqKey="Sohlberg E">E Sohlberg</name></author><author><name sortKey="Bjorklund, At" uniqKey="Bjorklund A">AT Björklund</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muntasell, A" uniqKey="Muntasell A">A Muntasell</name></author><author><name sortKey="L Pez Monta Es, M" uniqKey="L Pez Monta Es M">M López-Montañés</name></author><author><name sortKey="Vera, A" uniqKey="Vera A">A Vera</name></author><author><name sortKey="Heredia, G" uniqKey="Heredia G">G Heredia</name></author><author><name sortKey="Romo, N" uniqKey="Romo N">N Romo</name></author><author><name sortKey="Pe Afiel, J" uniqKey="Pe Afiel J">J Peñafiel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lopez Verges, S" uniqKey="Lopez Verges S">S Lopez-Vergès</name></author><author><name sortKey="Milush, Jm" uniqKey="Milush J">JM Milush</name></author><author><name sortKey="Schwartz, Bs" uniqKey="Schwartz B">BS Schwartz</name></author><author><name sortKey="Pando, Mj" uniqKey="Pando M">MJ Pando</name></author><author><name sortKey="Jarjoura, J" uniqKey="Jarjoura J">J Jarjoura</name></author><author><name sortKey="York, Va" uniqKey="York V">VA York</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, T" uniqKey="Zhang T">T Zhang</name></author><author><name sortKey="Scott, Jm" uniqKey="Scott J">JM Scott</name></author><author><name sortKey="Hwang, I" uniqKey="Hwang I">I Hwang</name></author><author><name sortKey="Kim, S" uniqKey="Kim S">S Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Costa Garcia, M" uniqKey="Costa Garcia M">M Costa-Garcia</name></author><author><name sortKey="Vera, A" uniqKey="Vera A">A Vera</name></author><author><name sortKey="Moraru, M" uniqKey="Moraru M">M Moraru</name></author><author><name sortKey="Vilches, C" uniqKey="Vilches C">C Vilches</name></author><author><name sortKey="L Pez Botet, M" uniqKey="L Pez Botet M">M López-Botet</name></author><author><name sortKey="Muntasell, A" uniqKey="Muntasell A">A Muntasell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Z" uniqKey="Wu Z">Z Wu</name></author><author><name sortKey="Sinzger, C" uniqKey="Sinzger C">C Sinzger</name></author><author><name sortKey="Frascaroli, G" uniqKey="Frascaroli G">G Frascaroli</name></author><author><name sortKey="Reichel, J" uniqKey="Reichel J">J Reichel</name></author><author><name sortKey="Bayer, C" uniqKey="Bayer C">C Bayer</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Redondo Pach N, D" uniqKey="Redondo Pach N D">D Redondo-Pachón</name></author><author><name sortKey="Crespo, M" uniqKey="Crespo M">M Crespo</name></author><author><name sortKey="Yelamos, J" uniqKey="Yelamos J">J Yélamos</name></author><author><name sortKey="Muntasell, A" uniqKey="Muntasell A">A Muntasell</name></author><author><name sortKey="Perez Saez, Mj" uniqKey="Perez Saez M">MJ Pérez-Sáez</name></author><author><name sortKey="Perez Fernandez, S" uniqKey="Perez Fernandez S">S Pérez-Fernández</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schlums, H" uniqKey="Schlums H">H Schlums</name></author><author><name sortKey="Cichocki, F" uniqKey="Cichocki F">F Cichocki</name></author><author><name sortKey="Tesi, B" uniqKey="Tesi B">B Tesi</name></author><author><name sortKey="Theorell, J" uniqKey="Theorell J">J Theorell</name></author><author><name sortKey="Beziat, V" uniqKey="Beziat V">V Beziat</name></author><author><name sortKey="Holmes, Td" uniqKey="Holmes T">TD Holmes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, J" uniqKey="Lee J">J Lee</name></author><author><name sortKey="Zhang, T" uniqKey="Zhang T">T Zhang</name></author><author><name sortKey="Hwang, I" uniqKey="Hwang I">I Hwang</name></author><author><name sortKey="Kim, A" uniqKey="Kim A">A Kim</name></author><author><name sortKey="Nitschke, L" uniqKey="Nitschke L">L Nitschke</name></author><author><name sortKey="Kim, M" uniqKey="Kim M">M Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kambayashi, T" uniqKey="Kambayashi T">T Kambayashi</name></author><author><name sortKey="Laufer, Tm" uniqKey="Laufer T">TM Laufer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fogli, M" uniqKey="Fogli M">M Fogli</name></author><author><name sortKey="Costa, P" uniqKey="Costa P">P Costa</name></author><author><name sortKey="Murdaca, G" uniqKey="Murdaca G">G Murdaca</name></author><author><name sortKey="Setti, M" uniqKey="Setti M">M Setti</name></author><author><name sortKey="Mingari, Mc" uniqKey="Mingari M">MC Mingari</name></author><author><name sortKey="Moretta, L" uniqKey="Moretta L">L Moretta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aranami, T" uniqKey="Aranami T">T Aranami</name></author><author><name sortKey="Miyake, S" uniqKey="Miyake S">S Miyake</name></author><author><name sortKey="Yamamura, T" uniqKey="Yamamura T">T Yamamura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cruz Gonzalez D De, J" uniqKey="Cruz Gonzalez D De J">J Cruz-González D de</name></author><author><name sortKey="G Mez Martin, D" uniqKey="G Mez Martin D">D Gómez-Martin</name></author><author><name sortKey="Layseca Espinosa, E" uniqKey="Layseca Espinosa E">E Layseca-Espinosa</name></author><author><name sortKey="Baranda, L" uniqKey="Baranda L">L Baranda</name></author><author><name sortKey="Abud Mendoza, C" uniqKey="Abud Mendoza C">C Abud-Mendoza</name></author><author><name sortKey="Alcocer Varela, J" uniqKey="Alcocer Varela J">J Alcocer-Varela</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sedlmayr, P" uniqKey="Sedlmayr P">P Sedlmayr</name></author><author><name sortKey="Schallhammer, L" uniqKey="Schallhammer L">L Schallhammer</name></author><author><name sortKey="Hammer, A" uniqKey="Hammer A">A Hammer</name></author><author><name sortKey="Wilders Truschnig, M" uniqKey="Wilders Truschnig M">M Wilders-Truschnig</name></author><author><name sortKey="Wintersteiger, R" uniqKey="Wintersteiger R">R Wintersteiger</name></author><author><name sortKey="Dohr, G" uniqKey="Dohr G">G Dohr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Erokhina, Sa" uniqKey="Erokhina S">SA Erokhina</name></author><author><name sortKey="Streltsova, Ma" uniqKey="Streltsova M">MA Streltsova</name></author><author><name sortKey="Kanevskiy, Lm" uniqKey="Kanevskiy L">LM Kanevskiy</name></author><author><name sortKey="Telford, Wg" uniqKey="Telford W">WG Telford</name></author><author><name sortKey="Sapozhnikov, Am" uniqKey="Sapozhnikov A">AM Sapozhnikov</name></author><author><name sortKey="Kovalenko, Ei" uniqKey="Kovalenko E">EI Kovalenko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="D Orazio, Ja" uniqKey="D Orazio J">JA D'Orazio</name></author><author><name sortKey="Stein Streilein, J" uniqKey="Stein Streilein J">J Stein-Streilein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Burt, Bm" uniqKey="Burt B">BM Burt</name></author><author><name sortKey="Plitas, G" uniqKey="Plitas G">G Plitas</name></author><author><name sortKey="Nguyen, Hm" uniqKey="Nguyen H">HM Nguyen</name></author><author><name sortKey="Stableford, Ja" uniqKey="Stableford J">JA Stableford</name></author><author><name sortKey="Bamboat, Zm" uniqKey="Bamboat Z">ZM Bamboat</name></author><author><name sortKey="Dematteo, Rp" uniqKey="Dematteo R">RP DeMatteo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, M" uniqKey="Kim M">M Kim</name></author><author><name sortKey="Osborne, Nr" uniqKey="Osborne N">NR Osborne</name></author><author><name sortKey="Zeng, W" uniqKey="Zeng W">W Zeng</name></author><author><name sortKey="Donaghy, H" uniqKey="Donaghy H">H Donaghy</name></author><author><name sortKey="Mckinnon, K" uniqKey="Mckinnon K">K McKinnon</name></author><author><name sortKey="Jackson, Dc" uniqKey="Jackson D">DC Jackson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oliphant, Cj" uniqKey="Oliphant C">CJ Oliphant</name></author><author><name sortKey="Hwang, Yy" uniqKey="Hwang Y">YY Hwang</name></author><author><name sortKey="Walker, Ja" uniqKey="Walker J">JA Walker</name></author><author><name sortKey="Salimi, M" uniqKey="Salimi M">M Salimi</name></author><author><name sortKey="Wong, Sh" uniqKey="Wong S">SH Wong</name></author><author><name sortKey="Brewer, Jm" uniqKey="Brewer J">JM Brewer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hepworth, Mr" uniqKey="Hepworth M">MR Hepworth</name></author><author><name sortKey="Monticelli, La" uniqKey="Monticelli L">LA Monticelli</name></author><author><name sortKey="Fung, Tc" uniqKey="Fung T">TC Fung</name></author><author><name sortKey="Ziegler, Cgk" uniqKey="Ziegler C">CGK Ziegler</name></author><author><name sortKey="Grunberg, S" uniqKey="Grunberg S">S Grunberg</name></author><author><name sortKey="Sinha, R" uniqKey="Sinha R">R Sinha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maecker, Ht" uniqKey="Maecker H">HT Maecker</name></author><author><name sortKey="Frey, T" uniqKey="Frey T">T Frey</name></author><author><name sortKey="Nomura, Le" uniqKey="Nomura L">LE Nomura</name></author><author><name sortKey="Trotter, J" uniqKey="Trotter J">J Trotter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muntasell, A" uniqKey="Muntasell A">A Muntasell</name></author><author><name sortKey="Magri, G" uniqKey="Magri G">G Magri</name></author><author><name sortKey="Pende, D" uniqKey="Pende D">D Pende</name></author><author><name sortKey="Angulo, A" uniqKey="Angulo A">A Angulo</name></author><author><name sortKey="L Pez Botet, M" uniqKey="L Pez Botet M">M López-Botet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kovalenko, Ei" uniqKey="Kovalenko E">EI Kovalenko</name></author><author><name sortKey="Streltsova, Ma" uniqKey="Streltsova M">MA Streltsova</name></author><author><name sortKey="Kanevskiy, Lm" uniqKey="Kanevskiy L">LM Kanevskiy</name></author><author><name sortKey="Erokhina, Sa" uniqKey="Erokhina S">SA Erokhina</name></author><author><name sortKey="Telford, Wg" uniqKey="Telford W">WG Telford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Magri, G" uniqKey="Magri G">G Magri</name></author><author><name sortKey="Muntasell, A" uniqKey="Muntasell A">A Muntasell</name></author><author><name sortKey="Romo, N" uniqKey="Romo N">N Romo</name></author><author><name sortKey="Saez Borderias, A" uniqKey="Saez Borderias A">A Sáez-Borderías</name></author><author><name sortKey="Pende, D" uniqKey="Pende D">D Pende</name></author><author><name sortKey="Geraghty, De" uniqKey="Geraghty D">DE Geraghty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name></author><author><name sortKey="Goodlett, Dr" uniqKey="Goodlett D">DR Goodlett</name></author><author><name sortKey="Ishitani, A" uniqKey="Ishitani A">A Ishitani</name></author><author><name sortKey="Marquardt, H" uniqKey="Marquardt H">H Marquardt</name></author><author><name sortKey="Geraghty, De" uniqKey="Geraghty D">DE Geraghty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muntasell, A" uniqKey="Muntasell A">A Muntasell</name></author><author><name sortKey="Pupuleku, A" uniqKey="Pupuleku A">A Pupuleku</name></author><author><name sortKey="Cisneros, E" uniqKey="Cisneros E">E Cisneros</name></author><author><name sortKey="Vera, A" uniqKey="Vera A">A Vera</name></author><author><name sortKey="Moraru, M" uniqKey="Moraru M">M Moraru</name></author><author><name sortKey="Vilches, C" uniqKey="Vilches C">C Vilches</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, Ll" uniqKey="Liu L">LL Liu</name></author><author><name sortKey="Landskron, J" uniqKey="Landskron J">J Landskron</name></author><author><name sortKey="Ask, Eh" uniqKey="Ask E">EH Ask</name></author><author><name sortKey="Enqvist, M" uniqKey="Enqvist M">M Enqvist</name></author><author><name sortKey="Sohlberg, E" uniqKey="Sohlberg E">E Sohlberg</name></author><author><name sortKey="Traherne, Ja" uniqKey="Traherne J">JA Traherne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muntasell, A" uniqKey="Muntasell A">A Muntasell</name></author><author><name sortKey="Costa Garcia, M" uniqKey="Costa Garcia M">M Costa-Garcia</name></author><author><name sortKey="Vera, A" uniqKey="Vera A">A Vera</name></author><author><name sortKey="Marina Garcia, Nn" uniqKey="Marina Garcia N">NN Marina-Garcia</name></author><author><name sortKey="Kirschning, Cj" uniqKey="Kirschning C">CJ Kirschning</name></author><author><name sortKey="L Pez Botet, M" uniqKey="L Pez Botet M">M López-Botet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sylwester, Aw" uniqKey="Sylwester A">AW Sylwester</name></author><author><name sortKey="Mitchell, Bl" uniqKey="Mitchell B">BL Mitchell</name></author><author><name sortKey="Edgar, Jb" uniqKey="Edgar J">JB Edgar</name></author><author><name sortKey="Taormina, C" uniqKey="Taormina C">C Taormina</name></author><author><name sortKey="Pelte, C" uniqKey="Pelte C">C Pelte</name></author><author><name sortKey="Ruchti, F" uniqKey="Ruchti F">F Ruchti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alonso Arias, R" uniqKey="Alonso Arias R">R Alonso-Arias</name></author><author><name sortKey="Moro Garcia, Ma" uniqKey="Moro Garcia M">MA Moro-García</name></author><author><name sortKey="L Pez Vazquez, A" uniqKey="L Pez Vazquez A">A López-Vázquez</name></author><author><name sortKey="Rodrigo, L" uniqKey="Rodrigo L">L Rodrigo</name></author><author><name sortKey="Baltar, J" uniqKey="Baltar J">J Baltar</name></author><author><name sortKey="Garcia, Fms" uniqKey="Garcia F">FMS García</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saez Borderias, A" uniqKey="Saez Borderias A">A Sáez-Borderías</name></author><author><name sortKey="Guma, M" uniqKey="Guma M">M Gumá</name></author><author><name sortKey="Angulo, A" uniqKey="Angulo A">A Angulo</name></author><author><name sortKey="Bellosillo, B" uniqKey="Bellosillo B">B Bellosillo</name></author><author><name sortKey="Pende, D" uniqKey="Pende D">D Pende</name></author><author><name sortKey="L Pez Botet, M" uniqKey="L Pez Botet M">M López-Botet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, Cm" uniqKey="Lau C">CM Lau</name></author><author><name sortKey="Adams, Nm" uniqKey="Adams N">NM Adams</name></author><author><name sortKey="Geary, Cd" uniqKey="Geary C">CD Geary</name></author><author><name sortKey="Weizman, O E" uniqKey="Weizman O">O-E Weizman</name></author><author><name sortKey="Rapp, M" uniqKey="Rapp M">M Rapp</name></author><author><name sortKey="Pritykin, Y" uniqKey="Pritykin Y">Y Pritykin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wright, Kl" uniqKey="Wright K">KL Wright</name></author><author><name sortKey="Ting, Jp Y" uniqKey="Ting J">JP-Y Ting</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roncarolo, Mg" uniqKey="Roncarolo M">MG Roncarolo</name></author><author><name sortKey="Bigler, M" uniqKey="Bigler M">M Bigler</name></author><author><name sortKey="Haanen, Jb" uniqKey="Haanen J">JB Haanen</name></author><author><name sortKey="Yssel, H" uniqKey="Yssel H">H Yssel</name></author><author><name sortKey="Bacchetta, R" uniqKey="Bacchetta R">R Bacchetta</name></author><author><name sortKey="De Vries, Je" uniqKey="De Vries J">JE de Vries</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boehme, Kw" uniqKey="Boehme K">KW Boehme</name></author><author><name sortKey="Guerrero, M" uniqKey="Guerrero M">M Guerrero</name></author><author><name sortKey="Compton, T" uniqKey="Compton T">T Compton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Romee, R" uniqKey="Romee R">R Romee</name></author><author><name sortKey="Foley, B" uniqKey="Foley B">B Foley</name></author><author><name sortKey="Lenvik, T" uniqKey="Lenvik T">T Lenvik</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Zhang, B" uniqKey="Zhang B">B Zhang</name></author><author><name sortKey="Ankarlo, D" uniqKey="Ankarlo D">D Ankarlo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goodier, Mr" uniqKey="Goodier M">MR Goodier</name></author><author><name sortKey="Lusa, C" uniqKey="Lusa C">C Lusa</name></author><author><name sortKey="Sherratt, S" uniqKey="Sherratt S">S Sherratt</name></author><author><name sortKey="Rodriguez Galan, A" uniqKey="Rodriguez Galan A">A Rodriguez-Galan</name></author><author><name sortKey="Behrens, R" uniqKey="Behrens R">R Behrens</name></author><author><name sortKey="Riley, Em" uniqKey="Riley E">EM Riley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lanzavecchia, A" uniqKey="Lanzavecchia A">A Lanzavecchia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bournazos, S" uniqKey="Bournazos S">S Bournazos</name></author><author><name sortKey="Wang, Tt" uniqKey="Wang T">TT Wang</name></author><author><name sortKey="Ravetch, Jv" uniqKey="Ravetch J">JV Ravetch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Platzer, B" uniqKey="Platzer B">B Platzer</name></author><author><name sortKey="Stout, M" uniqKey="Stout M">M Stout</name></author><author><name sortKey="Fiebiger, E" uniqKey="Fiebiger E">E Fiebiger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fletcher, Jm" uniqKey="Fletcher J">JM Fletcher</name></author><author><name sortKey="Vukmanovic Stejic, M" uniqKey="Vukmanovic Stejic M">M Vukmanovic-Stejic</name></author><author><name sortKey="Dunne, Pj" uniqKey="Dunne P">PJ Dunne</name></author><author><name sortKey="Birch, Ke" uniqKey="Birch K">KE Birch</name></author><author><name sortKey="Cook, Je" uniqKey="Cook J">JE Cook</name></author><author><name sortKey="Jackson, Se" uniqKey="Jackson S">SE Jackson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ventura, C" uniqKey="Ventura C">C Ventura</name></author><author><name sortKey="Bisceglia, H" uniqKey="Bisceglia H">H Bisceglia</name></author><author><name sortKey="Girerd Chambaz, Y" uniqKey="Girerd Chambaz Y">Y Girerd-Chambaz</name></author><author><name sortKey="Burdin, N" uniqKey="Burdin N">N Burdin</name></author><author><name sortKey="Chaux, P" uniqKey="Chaux P">P Chaux</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pachnio, A" uniqKey="Pachnio A">A Pachnio</name></author><author><name sortKey="Zuo, J" uniqKey="Zuo J">J Zuo</name></author><author><name sortKey="Ryan, Gb" uniqKey="Ryan G">GB Ryan</name></author><author><name sortKey="Begum, J" uniqKey="Begum J">J Begum</name></author><author><name sortKey="Moss, Pah" uniqKey="Moss P">PAH Moss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wunsch, M" uniqKey="Wunsch M">M Wunsch</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Hanson, J" uniqKey="Hanson J">J Hanson</name></author><author><name sortKey="Caspell, R" uniqKey="Caspell R">R Caspell</name></author><author><name sortKey="Karulin, Ay" uniqKey="Karulin A">AY Karulin</name></author><author><name sortKey="Recks, Ms" uniqKey="Recks M">MS Recks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Watchmaker, Pb" uniqKey="Watchmaker P">PB Watchmaker</name></author><author><name sortKey="Urban, Ja" uniqKey="Urban J">JA Urban</name></author><author><name sortKey="Berk, E" uniqKey="Berk E">E Berk</name></author><author><name sortKey="Nakamura, Y" uniqKey="Nakamura Y">Y Nakamura</name></author><author><name sortKey="Mailliard, Rb" uniqKey="Mailliard 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Dunn</name></author><author><name sortKey="Boname, Jm" uniqKey="Boname J">JM Boname</name></author><author><name sortKey="Lewinsohn, Dm" uniqKey="Lewinsohn D">DM Lewinsohn</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Espagne</li></country></list><tree><country name="Espagne"><noRegion><name sortKey="Costa Garcia, Marcel" sort="Costa Garcia, Marcel" uniqKey="Costa Garcia M" first="Marcel" last="Costa-García">Marcel Costa-García</name></noRegion><name sortKey="Ataya, Michelle" sort="Ataya, Michelle" uniqKey="Ataya M" first="Michelle" last="Ataya">Michelle Ataya</name><name sortKey="L Pez Botet, Miguel" sort="L Pez Botet, Miguel" uniqKey="L Pez Botet M" first="Miguel" last="L Pez-Botet">Miguel L Pez-Botet</name><name sortKey="L Pez Botet, Miguel" sort="L Pez Botet, Miguel" uniqKey="L Pez Botet M" first="Miguel" last="L Pez-Botet">Miguel L Pez-Botet</name><name sortKey="Moraru, Manuela" sort="Moraru, Manuela" uniqKey="Moraru M" first="Manuela" last="Moraru">Manuela Moraru</name><name sortKey="Muntasell, Aura" sort="Muntasell, Aura" uniqKey="Muntasell A" first="Aura" last="Muntasell">Aura Muntasell</name><name sortKey="Vilches, Carlos" sort="Vilches, Carlos" uniqKey="Vilches C" first="Carlos" last="Vilches">Carlos Vilches</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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